Fee Download Ion Channels of Excitable Membranes, Third Edition, by Bertil Hille
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Ion Channels of Excitable Membranes, Third Edition, by Bertil Hille
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Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded Third Edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.
- Sales Rank: #432887 in Books
- Published on: 2001-07-16
- Original language: English
- Number of items: 1
- Dimensions: 9.50" h x 7.25" w x 1.25" l, 3.36 pounds
- Binding: Hardcover
- 814 pages
- electrophysiology
- plasma membrane biophysics
- complex interplay of ionic channels
- models of single channels
Review
"Earlier versions were notable achievements for their clarity and broad utility. The third edition is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book . . . remains a resource for practitioners of the craft and the essential guide to the electrophysiological universe." --Steven A. N. Goldstein, Cell
About the Author
BERTIL HILLE teaches at the University of Washington. He won the 1999 Albert Lasker Award.
Most helpful customer reviews
8 of 9 people found the following review helpful.
A classic. Still authoritative.
By Jihwan Myung
This is an authoritative textbook on ion channels that is often quoted in numerous textbooks in neurophysiology. Hille himself has contributed a lot in this field. The Hogkin-Huxley model is the de facto standard model in neurophysiology but certain things about neurons cannot be explained only with voltage-controlled sodium and potassium channels. With the patch-clamp technique, we have found a way to explore other interesting channles. To remind you, there are a world of ion channels! Hille's textbook show there are indeed a variety of channels most of which are poorly understood. As a reviewer below has commented, it also gives a unique insight into the history of neural membrane research. Concepts are explained with clearity. Details measurement techniques.
30 of 36 people found the following review helpful.
Destined to become an Oprah Book Club selection
By Syn Apse
Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes."
Even after my fifth reading, that line still gives me the shivers.
But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work.
It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush!
2 of 2 people found the following review helpful.
A staple of electrophysiology
By Tricia A. Hardt
If you are interested in the science of electrophysiology, this is your textbook. Starts with basic, ground concepts and works it way up. Begin with an intro of Ohm's law, etc. and the history of electrophysiology and moves to more in depth material for each ion channel. The only drawback is that this is the most up to date version, so there has been some progress since then. But for anyone involved in patch clamping, this is a must read.
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